RapamycinFungusV1, Main, Exploration, bibRecord, 000528

Phenotypic characterization of SETD3 knockout Drosophila.

Identifieur interne : 000528 ( Main/Exploration ); précédent : 000527; suivant : 000529

Phenotypic characterization of SETD3 knockout Drosophila.

Auteurs : Marcel Tiebe [Allemagne] ; Marilena Lutz [Allemagne] ; Dan Levy [Israël] ; Aurelio A. Teleman [Allemagne]

Source :

PloS one [ 1932-6203 ] ; 2018.

RBID : pubmed:30067821

Descripteurs français

KwdFr :
- Animaux (MeSH), Complexe-1 cible mécanistique de la rapamycine (métabolisme), Drosophila (croissance et développement), Drosophila (cytologie), Drosophila (génétique), Fécondité (MeSH), Histone-lysine N-methyltransferase (génétique), Hypoxie cellulaire (MeSH), Lignée cellulaire (MeSH), Phénotype (MeSH), Prolifération cellulaire (MeSH), Protéines de Drosophila (génétique), Protéines de Drosophila (métabolisme), Techniques de knock-out de gènes (MeSH).
MESH :
- croissance et développement : Drosophila.
- cytologie : Drosophila.
- génétique : Drosophila, Histone-lysine N-methyltransferase, Protéines de Drosophila.
- métabolisme : Complexe-1 cible mécanistique de la rapamycine, Protéines de Drosophila.
- Animaux, Fécondité, Hypoxie cellulaire, Lignée cellulaire, Phénotype, Prolifération cellulaire, Techniques de knock-out de gènes.

English descriptors

KwdEn :
- Animals (MeSH), Cell Hypoxia (MeSH), Cell Line (MeSH), Cell Proliferation (MeSH), Drosophila (cytology), Drosophila (genetics), Drosophila (growth & development), Drosophila Proteins (genetics), Drosophila Proteins (metabolism), Fertility (MeSH), Gene Knockout Techniques (MeSH), Histone-Lysine N-Methyltransferase (genetics), Mechanistic Target of Rapamycin Complex 1 (metabolism), Phenotype (MeSH).
MESH :
- chemical , genetics : Drosophila Proteins, Histone-Lysine N-Methyltransferase.
- cytology : Drosophila.
- genetics : Drosophila.
- growth & development : Drosophila.
- chemical , metabolism : Drosophila Proteins, Mechanistic Target of Rapamycin Complex 1.
- Animals, Cell Hypoxia, Cell Line, Cell Proliferation, Fertility, Gene Knockout Techniques, Phenotype.

Abstract

Lysine methylation is a reversible post-translational modification that affects protein function. Lysine methylation is involved in regulating the function of both histone and non-histone proteins, thereby influencing both cellular transcription and the activation of signaling pathways. To date, only a few lysine methyltransferases have been studied in depth. Here, we study the Drosophila homolog of the human lysine methyltransferase SETD3, CG32732/dSETD3. Since mammalian SETD3 is involved in cell proliferation, we tested the effect of dSETD3 on proliferation and growth of Drosophila S2 cells and whole flies. Knockdown of dSETD3 did not alter mTORC1 activity nor proliferation rate of S2 cells. Complete knock-out of dSETD3 in Drosophila flies did not affect their weight, growth rate or fertility. dSETD3 KO flies showed normal responses to starvation and hypoxia. In sum, we could not identify any clear phenotypes for SETD3 knockout animals, indicating that additional work will be required to elucidate the molecular and physiological function of this highly conserved enzyme.

DOI: 10.1371/journal.pone.0201609
PubMed: 30067821
PubMed Central: PMC6070285

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000491
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Le document en format XML

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<front><div type="abstract" xml:lang="en">Lysine methylation is a reversible post-translational modification that affects protein function. Lysine methylation is involved in regulating the function of both histone and non-histone proteins, thereby influencing both cellular transcription and the activation of signaling pathways. To date, only a few lysine methyltransferases have been studied in depth. Here, we study the Drosophila homolog of the human lysine methyltransferase SETD3, CG32732/dSETD3. Since mammalian SETD3 is involved in cell proliferation, we tested the effect of dSETD3 on proliferation and growth of Drosophila S2 cells and whole flies. Knockdown of dSETD3 did not alter mTORC1 activity nor proliferation rate of S2 cells. Complete knock-out of dSETD3 in Drosophila flies did not affect their weight, growth rate or fertility. dSETD3 KO flies showed normal responses to starvation and hypoxia. In sum, we could not identify any clear phenotypes for SETD3 knockout animals, indicating that additional work will be required to elucidate the molecular and physiological function of this highly conserved enzyme.</div>
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<Abstract><AbstractText>Lysine methylation is a reversible post-translational modification that affects protein function. Lysine methylation is involved in regulating the function of both histone and non-histone proteins, thereby influencing both cellular transcription and the activation of signaling pathways. To date, only a few lysine methyltransferases have been studied in depth. Here, we study the Drosophila homolog of the human lysine methyltransferase SETD3, CG32732/dSETD3. Since mammalian SETD3 is involved in cell proliferation, we tested the effect of dSETD3 on proliferation and growth of Drosophila S2 cells and whole flies. Knockdown of dSETD3 did not alter mTORC1 activity nor proliferation rate of S2 cells. Complete knock-out of dSETD3 in Drosophila flies did not affect their weight, growth rate or fertility. dSETD3 KO flies showed normal responses to starvation and hypoxia. In sum, we could not identify any clear phenotypes for SETD3 knockout animals, indicating that additional work will be required to elucidate the molecular and physiological function of this highly conserved enzyme.</AbstractText>
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Phenotypic characterization of SETD3 knockout Drosophila.

Phenotypic characterization of SETD3 knockout Drosophila.

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